Safety and tolerability of carbamylated erythropoietin in Friedreich's ataxia.
Identifieur interne : 000424 ( Main/Exploration ); précédent : 000423; suivant : 000425Safety and tolerability of carbamylated erythropoietin in Friedreich's ataxia.
Auteurs : Sylvia Boesch [Autriche] ; Wolfgang Nachbauer ; Caterina Mariotti ; Francesco Sacca ; Alessandro Filla ; Thomas Klockgether ; Thomas Klopstock ; Ludger Schöls ; Heike Jacobi ; Boriana Büchner ; Jennifer Müller Vom Hagen ; Lorenzo Nanetti ; Karen ManicomSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Erythropoietin.
- chemical , analogs & derivatives : Erythropoietin.
- chemical , metabolism : Biological Markers, Iron-Binding Proteins.
- chemical , therapeutic use : Erythropoietin.
- drug therapy : Friedreich Ataxia.
- Adult, Double-Blind Method, Female, Humans, Male, Treatment Outcome.
Abstract
Erythropoietin (EPO) derivatives have been found to increase frataxin levels in Friedreich's ataxia (FRDA) in vitro. This multicenter, double-blind, placebo-controlled, phase II clinical trial aimed to evaluate the safety and tolerability of Lu AA24493 (carbamylated EPO; CEPO).
DOI: 10.1002/mds.25836
PubMed: 24515352
Affiliations:
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Le document en format XML
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(metabolism)</term><term>Double-Blind Method</term><term>Erythropoietin (adverse effects)</term><term>Erythropoietin (analogs & derivatives)</term><term>Erythropoietin (therapeutic use)</term><term>Female</term><term>Friedreich Ataxia (drug therapy)</term><term>Humans</term><term>Iron-Binding Proteins (metabolism)</term><term>Male</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Erythropoietin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Erythropoietin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biological Markers</term><term>Iron-Binding Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Erythropoietin</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Friedreich Ataxia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Erythropoietin (EPO) derivatives have been found to increase frataxin levels in Friedreich's ataxia (FRDA) in vitro. This multicenter, double-blind, placebo-controlled, phase II clinical trial aimed to evaluate the safety and tolerability of Lu AA24493 (carbamylated EPO; CEPO).</div></front></TEI><affiliations><list><country><li>Autriche</li></country></list><tree><noCountry><name sortKey="Buchner, Boriana" sort="Buchner, Boriana" uniqKey="Buchner B" first="Boriana" last="Büchner">Boriana Büchner</name><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name><name sortKey="Jacobi, Heike" sort="Jacobi, Heike" uniqKey="Jacobi H" first="Heike" last="Jacobi">Heike Jacobi</name><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name><name sortKey="Manicom, Karen" sort="Manicom, Karen" uniqKey="Manicom K" first="Karen" last="Manicom">Karen Manicom</name><name sortKey="Mariotti, Caterina" sort="Mariotti, Caterina" uniqKey="Mariotti C" first="Caterina" last="Mariotti">Caterina Mariotti</name><name sortKey="Nachbauer, Wolfgang" sort="Nachbauer, Wolfgang" uniqKey="Nachbauer W" first="Wolfgang" last="Nachbauer">Wolfgang Nachbauer</name><name sortKey="Nanetti, Lorenzo" sort="Nanetti, Lorenzo" uniqKey="Nanetti L" first="Lorenzo" last="Nanetti">Lorenzo Nanetti</name><name sortKey="Sacca, Francesco" sort="Sacca, Francesco" uniqKey="Sacca F" first="Francesco" last="Sacca">Francesco Sacca</name><name sortKey="Schols, Ludger" sort="Schols, Ludger" uniqKey="Schols L" first="Ludger" last="Schöls">Ludger Schöls</name><name sortKey="Vom Hagen, Jennifer Muller" sort="Vom Hagen, Jennifer Muller" uniqKey="Vom Hagen J" first="Jennifer Müller" last="Vom Hagen">Jennifer Müller Vom Hagen</name></noCountry><country name="Autriche"><noRegion><name sortKey="Boesch, Sylvia" sort="Boesch, Sylvia" uniqKey="Boesch S" first="Sylvia" last="Boesch">Sylvia Boesch</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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